Mark Daly, PhD: Progress in Schizophrenia: From Genome to GWAS to Medicine

FESCH.TV INFORMIERT:

Schizophrenia has a complex genetic architecture made up of both common and rare variation. Rare risk variants under strong negative selection are often de novo and may confer substantial risk—with both point mutations and CNVs often studied separately—while common variants at many sites drive
the majority of high heritability in a polygenic fashion. I will review the progress in gene discovery over the past 15 years, how it fits with the clear natural selection acting against schizophrenia and other severe neuropsychiatric and neurodevelopmental phenotypes, and what prospects these data hold to revealing actionable biology and therapeutic hypotheses.